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Anti-CD45 PTPRC Antibody

Boster Bio Anti-CD45 PTPRC Antibody catalog # A00555. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Receptor-type tyrosine-protein phosphatase C;3.1.3.48; Leukocyte common antigen; L-CA; T200; CD45; PTPRC; CD45

Gene Name

PTPRC

UniProt

P08575

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human CD45. AA range:981-1030

Applications

WB, IHC, IF, ELISA

Purification

Immunogen affinity purified

Concentration

1 mg/mL

Form

Liquid

Function

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

147254 MW

Gene Name Synonym

Receptor-type tyrosine-protein phosphatase C

Subcellular Location

Membrane ; Single-pass type I membrane protein . Membrane raft . Colocalized with DPP4 in membrane rafts.

Isotype

IgG

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

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