Anti-PR (phospho-S190) PGR Antibody
Boster Bio Anti-PR (phospho-S190) PGR Antibody catalog # A00541S190. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3; PGR; NR3C3
Gene Name
PGR
UniProt
P06401
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic phosphopeptide derived from human PR around the phosphorylation site of Serine 190.
Clonality
Polyclonal
Tissue Specificity
In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of the menstrual cycle. Expression of isoform B but not of isoform A persists in the glands during mid-secretory phase. In the stroma, isoform A is the predominant form throughout the cycle. Heterogeneous isoform expression between the glands of the endometrium basalis and functionalis is implying region- specific responses to hormonal stimuli.
Applications
IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
98981 MW
Applications Notes
IHC: 1:50-1:200
Gene Name Synonym
Progesterone receptor
Subcellular Location
Nucleus. Cytoplasm. Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G (1) and G (2) /M phases.
Protein Name
Progesterone receptor
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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