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Anti-Exonuclease 1 Exo1 Antibody

Boster Bio Anti-Exonuclease 1 Exo1 Antibody catalog # A00536. Tested in WB, IF, ELISA applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Exonuclease 1; hExo1;3.1.-.-; Exonuclease I; hExoI; EXO1; EXOI, HEX1

Gene Name

EXO1

UniProt

Q9UQ84

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human EXO1. AA range:61-110

Clonality

Polyclonal

Tissue Specificity

Highly expressed in bone marrow, testis and thymus. Expressed at lower levels in colon, lymph nodes, ovary, placenta, prostate, small intestine, spleen and stomach. .

Applications

WB, IF, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.

Concentration

1 mg/mL

Form

Liquid

Function

5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch- containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

94103 MW

Gene Name Synonym

Exonuclease 1

Subcellular Location

Nucleus . Colocalizes with PCNA to discrete nuclear foci in S-phase.

Isotype

IgG

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

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