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Anti-IDH2 Antibody

Boster Bio Anti-IDH2 Antibody (Catalog # A00510) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD (+) as the electron acceptor and the other NADP (+) . Two NADP (+) -dependent isocitrate dehydrogenases have been found as homodimer: IDH1 is predominantly cytosolic and peroxisomal and IDH2 is mitochondrial. Both IDH1 and IDH2 play significant roles in the tricarboxylic acid cycle (TCA), and defects in IDH1 as well as IDH2 have been implicated in the development of glioma as well as other malignancies.

Synonyms

IDH, IDP, IDHM, IDPM, ICD-M, D2HGA2, mNADP-IDHICD-M, IDH

Gene Name

IDH2

UniProt

P48735

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

IDH2 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human IDH2. The immunogen is located within the first 50 amino acids of IDH2.

Clonality

Polyclonal

Applications

ELISA, WB, IHC-P, IF

Field of Research

Homeostasis

Purification

IDH2 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.

Storage Conditions

Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

50909 MW

Gene Name Synonym

Isocitrate dehydrogenase 2 (NADP+), mitochondrial

Subcellular Location

Mitochondrion.

Prediction Reactivity

Bovine

Protein Name

Isocitrate dehydrogenase 2 (NADP+), mitochondrial

Isotype

IgG

Contents

IDH2 Antibody is supplied in PBS containing 0.02% sodium azide.

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