Anti-SARS Antibody
Boster Bio Anti-SARS Antibody catalog # A00501. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Serine--tRNA ligase, cytoplasmic;6.1.1.11
Gene Name
SARS
UniProt
P49591
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human SARS (NP_006504.2) .
Clonality
Polyclonal
Tissue Specificity
Brain.
Applications
WB, IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Catalyzes the attachment of serine to tRNA (Ser) in a two-step reaction: serine is first activated by ATP to form Ser- AMP and then transferred to the acceptor end of tRNA (Ser) (PubMed:22353712, PubMed:24095058, PubMed:9431993, PubMed:26433229, PubMed:28236339) . Is probably also able to aminoacylate tRNA (Sec) with serine, to form the misacylated tRNA L-seryl-tRNA (Sec), which will be further converted into selenocysteinyl-tRNA (Sec) (PubMed:9431993, PubMed:26433229, PubMed:28236339) . In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000) . Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16) . Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
58777 MW
Gene Name Synonym
Serine--tRNA ligase, cytoplasmic
Subcellular Location
Cytoplasm
Protein Name
Serine--tRNA ligase, cytoplasmic
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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