Anti-XPC Antibody
Boster Bio Anti-XPC Antibody catalog # A00473. Tested in WB, IHC, IP applications. This antibody reacts with Human.
Product Specifications
Synonyms
DNA repair protein complementing XP-C cells; Xeroderma pigmentosum group C-complementing protein; p125; XPC; XPCC
Gene Name
XPC
UniProt
Q01831
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant fusion protein of human XPC (NP_004619.3) .
Clonality
Polyclonal
Applications
WB, IHC, IP
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA- binding activity.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
105953 MW
Gene Name Synonym
DNA repair protein complementing XP-C cells
Subcellular Location
Nucleus. Cytoplasm. Omnipresent in the nucleus and consistently associates with and dissociates from DNA in the absence of DNA damage. Continuously shuttles between the cytoplasm and the nucleus, which is impeded by the presence of NER lesions.
Protein Name
DNA repair protein complementing XP-C cells
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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