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Anti-CAD Antibody (Center)

Boster Bio Anti-CAD Antibody (Center) (Catalog # A00463-3) . Tested in WB, IHC-P, Flow Cytometry application (s) . This antibody reacts with Human.

Product Specifications

Background

The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.

Synonyms

CAD protein, Glutamine-dependent carbamoyl-phosphate synthase, Aspartate carbamoyltransferase, Dihydroorotase, CAD

Gene Name

CAD

UniProt

P27708

Host

Rabbit

Reactivity

Human

Immunogen

This CAD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 780-809 amino acids from the Central region of human CAD.

Clonality

Polyclonal

Applications

WB, IHC-P, Flow Cytometry

Field of Research

Cell Biology, Metabolism

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) .

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

242984 Da

Subcellular Location

Cytoplasm. Nucleus. Note=Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth

Prediction Reactivity

Mouse

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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