Anti-Smoothened homolog SMO Antibody
Boster Bio Anti-Smoothened homolog SMO Antibody catalog # A00451. Tested in WB applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Smoothened homolog; SMO; Protein Gx; SMO; SMOH
Gene Name
SMO
UniProt
Q99835
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human SMO (NP_005622.1) .
Clonality
Polyclonal
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO) . Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253) . Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
86397 MW
Applications Notes
WB: 1:500-1:2000
Gene Name Synonym
Smoothened homolog
Subcellular Location
Membrane
Protein Name
Smoothened homolog
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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