Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-AIM2 (A78) Antibody

Boster Bio Anti-AIM2 (A78) Antibody catalog # A00443. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Interferon-inducible protein AIM2; Absent in melanoma 2; AIM2

Gene Name

AIM2

UniProt

O14862

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 51-100 of Human AIM2.

Clonality

Polyclonal

Tissue Specificity

Expressed in spleen, small intestine, peripheral blood leukocytes, and testis.

Applications

IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity) . Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

38954 MW

Applications Notes

IHC: 1:50-1:200

Gene Name Synonym

Interferon-inducible protein AIM2

Subcellular Location

Nucleus. Cytoplasm. Activated inflammasomes can aggregate in the cytosol as speck-like particles.

Protein Name

Interferon-inducible protein AIM2

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Human REPS2 (NM_004726) AAV Particle
RC217778A1V 250 µL

Human REPS2 (NM_004726) AAV Particle

Ask
View Details
Sodium Orthovanadate
TRC-S655003-5G 5 g

Sodium Orthovanadate

Ask
View Details
Rabbit Polyclonal PAD3 Antibody [Allophycocyanin]
NBP2-97680APC 0.1 mL

Rabbit Polyclonal PAD3 Antibody [Allophycocyanin]

Ask
View Details
ALPHA 2 MACROGLOBULIN
GWB-1A733A 1 mg

ALPHA 2 MACROGLOBULIN

Ask
View Details
Gemin 8 (GEMIN8) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI2G6]
TA805837BM 100 µL

Gemin 8 (GEMIN8) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI2G6]

Ask
View Details