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Anti-Acidic mammalian chitinase CHIA Antibody

Boster Bio Anti-Acidic mammalian chitinase CHIA Antibody catalog # A00437. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Acidic mammalian chitinase; AMCase;3.2.1.14; Lung-specific protein TSA1902; CHIA

Gene Name

CHIA

UniProt

Q9BZP6

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein of human CHIA (NP_001244932.1) .

Clonality

Polyclonal

Tissue Specificity

Detected in lung epithelial cells from asthma patients (at protein level) . Highly expressed in stomach. Detected at lower levels in lung.

Applications

WB, IHC, ICC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

52271 MW

Gene Name Synonym

Acidic mammalian chitinase

Subcellular Location

Isoform 1: Secreted. Secretion depends on EGFR activity.

Protein Name

Acidic mammalian chitinase

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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