Anti-EPOR Antibody (C-term)
Boster Bio Anti-EPOR Antibody (C-term) (Catalog # A00427-3) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Human.
Product Specifications
Background
Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.
Synonyms
Erythropoietin receptor, EPO-R, EPOR
Gene Name
EPOR
UniProt
P19235
Host
Rabbit
Reactivity
Human
Immunogen
This EPOR antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 470-504 amino acids from the C-terminal region of human EPOR.
Clonality
Polyclonal
Tissue Specificity
Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow Isoform EPOR-T is the most abundant from in early-stage erythroid progenitor cells
Applications
WB, Flow Cytometry
Field of Research
Cardiovascular, Immunology, Signal Transduction, Stem Cells
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
55065 Da
Subcellular Location
Cell membrane; Single-pass type I membrane protein
Isotype
Rabbit IgG
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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