Anti-Erythropoietin receptor EpoR Antibody
Boster Bio Anti-Erythropoietin receptor EpoR Antibody catalog # A00427. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Erythropoietin receptor; EPO-R; EPOR
Gene Name
EPOR
UniProt
P19235
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human EPOR (NP_000112.1) .
Clonality
Polyclonal
Tissue Specificity
Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early- stage erythroid progenitor cells.
Applications
WB, ICC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
55065 MW
Gene Name Synonym
Erythropoietin receptor
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Name
Erythropoietin receptor
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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