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Anti-C-C chemokine receptor type 7 CCR7 Antibody

Boster Bio Anti-C-C chemokine receptor type 7 CCR7 Antibody (Catalog # A00390) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

Product Specifications

Background

The CCR7 protein is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation (1,2) . The chemokine (C-C motif) ligand 19 (CCL19) has been reported to be a specific ligand of this receptor (3) .

Synonyms

BLR2, EBI1, CD197, CDw197, CMKBR7, EVI1, C-C chemokine receptor type 7, BLR2, C-C CKR-7

Gene Name

CCR7

UniProt

P32248

Host

Rabbit

Reactivity

Human

Cross Reactivity

CCR7 antibody is human specific. CCR7 antibody is predicted to not cross-react with other CCR proteins.

Immunogen

CCR7 antibody was raised against a 15 amino acid peptide near the center of human CCR7. The immunogen is located within amino acids 180 - 230 of CCR7.

Clonality

Polyclonal

Tissue Specificity

Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Chemokines, Cytokines

Purification

CCR7 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.

Storage Conditions

CCR7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

42874 MW

Gene Name Synonym

Chemokine (C-C motif) receptor 7

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Name

Chemokine (C-C motif) receptor 7

Isotype

IgG

Contents

CCR7 antibody is supplied in PBS containing 0.02% sodium azide.

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