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Anti-GRB2 Antibody (Y209)

Boster Bio Anti-GRB2 Antibody (Y209) (Catalog # A00351) . Tested in WB, IHC-P application (s) . This antibody reacts with Human.

Product Specifications

Background

GRB2 binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway.

Synonyms

Growth factor receptor-bound protein 2, Adapter protein GRB2, Protein Ash, SH2/SH3 adapter GRB2, GRB2, ASH

Gene Name

GRB2

UniProt

P62993

Host

Rabbit

Reactivity

Human

Immunogen

This GRB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-216 amino acids from human GRB2.

Clonality

Polyclonal

Applications

WB, IHC-P

Field of Research

Cancer, Signal Transduction, Viral process, Host-Virus Interaction, T Cells, Chemokine signaling, Inflammation, Interleukins

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

25206 Da

Subcellular Location

Nucleus. Cytoplasm. Endosome Golgi apparatus {ECO:0000250|UniProtKB:Q60631}

Prediction Reactivity

Xenopus, Chicken, Mouse, Rat

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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