Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity) (PubMed:10646604) . Associates with KCNE beta subunits that modulates current kinetics (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505, PubMed:19687231) . Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505) . Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity) . During beta- adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I (Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I (Ks) (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505) . Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (PubMed:10713961) . When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (PubMed:10646604) . This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity) . During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity) . Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity) . When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505) . When associated with KCNE4, inhibits voltage-gated potassium channel activity (PubMed:19687231) . When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (PubMed:12324418) . Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium channel activity (PubMed:24855057) . Binds with phosphatidylinositol 4,5- bisphosphate (PubMed:25037568) .
