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Anti-CXCR3 Antibody

Boster Bio Anti-CXCR3 Antibody (Catalog # A00295) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

The CXCR3 protein is a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-gamma), CXCL10/IP10 (interferon-gamma-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell alpha-chemoattractant) (reviewed in 1) . Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration (2) . Similar to other chemokine receptors such as CXCR4, CXCR3 has been implicated in several malignancies as a biomarker of tumor behavior as well as a potential therapeutic target (3) .

Synonyms

GPR9, MigR, CD182, CD183, Mig-R, CKR-L2, CMKAR3, IP10-R, GPR9, C-X-C chemokine receptor type 3, CXC-R3

Gene Name

CXCR3

UniProt

P49682

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

CXCR3 antibody is human, mouse and rat reactive. At least two isoforms of CXCR3 are known to exist; this antibody will detect both isoforms.

Immunogen

CXCR3 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human CXCR3 . The immunogen is located within the last 50 amino acids of CXCR3.

Clonality

Polyclonal

Tissue Specificity

Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level) .

Applications

ELISA, WB, ICC, IF

Field of Research

Chemokines, Cytokines

Purification

CXCR3 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716) . Binds to CCL21. Probably promotes cell chemotaxis response.

Storage Conditions

CXCR3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

40660 MW

Gene Name Synonym

Chemokine (C-X-C motif) receptor 3

Subcellular Location

Isoform 1: Cell membrane

Prediction Reactivity

Goat, Bovine

Protein Name

Chemokine (C-X-C motif) receptor 3

Isotype

IgG

Contents

CXCR3 antibody is supplied in PBS containing 0.02% sodium azide.

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