Anti-SREBP-1 (phospho-S439) SREBF1 Antibody
Boster Bio Anti-SREBP-1 (phospho-S439) SREBF1 Antibody catalog # A00282S439. Tested in WB applications. This antibody reacts with Human, Rat, Mouse.
Product Specifications
Synonyms
Sterol regulatory element-binding protein 1; SREBP-1; Class D basic helix-loop-helix protein 1; bHLHd1; Sterol regulatory element-binding transcription factor 1; Processed sterol regulatory element-binding protein 1; SREBF1; BHLHD1, SREBP1
Gene Name
SREBF1
UniProt
P36956
Host
Rabbit
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic phosphopeptide derived from human SREBP-1 around the phosphorylation site of Serine 439
Clonality
Polyclonal
Tissue Specificity
Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1mg/mL
Form
Liquid
Function
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity) . Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') . Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
121675 MW
Applications Notes
WB: 1:500-1:1000
Gene Name Synonym
Sterol regulatory element-binding protein 1
Subcellular Location
Endoplasmic reticulum membrane
Protein Name
Sterol regulatory element-binding protein 1
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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