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Anti-CHEK2 Antibody (N-term)

Boster Bio Anti-CHEK2 Antibody (N-term) (Catalog # A00277-1) . Tested in WB, IF, Flow Cytometry, IHC-P application (s) . This antibody reacts with Human.

Product Specifications

Background

CHEK2 is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53.

Synonyms

Serine/threonine-protein kinase Chk2, CHK2 checkpoint homolog, Cds1 homolog, Hucds1, hCds1, Checkpoint kinase 2, CHEK2, CDS1, CHK2, RAD53

Gene Name

CHEK2

UniProt

O96017

Host

Rabbit

Reactivity

Human

Immunogen

This CHEK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-141 amino acids from the N-terminal region of human CHEK2.

Clonality

Polyclonal

Tissue Specificity

High expression is found in testis, spleen, colon and peripheral blood leukocytes. Low expression is found in other tissues

Applications

WB, IF, Flow Cytometry, IHC-P

Field of Research

Cancer

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

25361978

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

60915 Da

Subcellular Location

[Isoform 2]: Nucleus. Note=Isoform 10 is present throughout the cell [Isoform 7]: Nucleus. [Isoform 12]: Nucleus.

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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