Anti-FoxO3A (phospho-S253) Antibody
Boster Bio Anti-FoxO3A (phospho-S253) Antibody catalog # A00252S253. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Forkhead box protein O3 ; AF6q21 protein
Gene Name
FOXO3
UniProt
O43524
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthetic phosphopeptide derived from human FOXO3A around the phosphorylation site of Serine 253.
Clonality
Polyclonal
Tissue Specificity
Ubiquitous.
Applications
WB, IHC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106) . Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' (PubMed:21329882) . Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882) . In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
71277 MW
Gene Name Synonym
Forkhead box protein O3
Subcellular Location
Cytoplasm, cytosol
Protein Name
Forkhead box protein O3
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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