Anti-Wilms tumor protein WT1 Antibody
Boster Bio Anti-Wilms tumor protein WT1 Antibody catalog # A00199. Tested in WB, IF, IHC, ELISA applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Wilms tumor protein; WT33; WT1
Gene Name
WT1
UniProt
P19544
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
KLH conjugated synthetic peptide derived from human WT1: 301-400/449
Clonality
Polyclonal
Tissue Specificity
Expressed in the kidney and a subset of hematopoietic cells.
Applications
WB, IF, IHC, ELISA
Purification
ProA affinity purified
Concentration
1 mg/mL
Form
Liquid
Function
Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533) . Recognizes and binds to the DNA sequence 5'-GCG (T/G) GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363) . Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190) . Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801) . Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
49188 MW
Gene Name Synonym
Wilms tumor protein
Subcellular Location
Nucleus
Protein Name
Wilms tumor protein
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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