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Anti-SHP-2 (phospho-Y542) PTPN11 Antibody

Boster Bio Anti-SHP-2 (phospho-Y542) PTPN11 Antibody catalog # A00150Y542. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Tyrosine-protein phosphatase non-receptor type 11;3.1.3.48

Gene Name

PTPN11

UniProt

Q06124

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic phosphopeptide derived from human SHP-2 around the phosphorylation site of Tyrosine 542.

Clonality

Polyclonal

Tissue Specificity

Widely expressed, with highest levels in heart, brain, and skeletal muscle.

Applications

WB, IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573) . Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573) . Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

68436 MW

Gene Name Synonym

Tyrosine-protein phosphatase non-receptor type 11

Subcellular Location

Cytoplasm

Protein Name

Tyrosine-protein phosphatase non-receptor type 11

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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