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Anti-p21 (phospho-T145) CDKN1A Antibody

Boster Bio Anti-p21 (phospho-T145) CDKN1A Antibody catalog # A00145T145. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21; CDKN1A; CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1

Gene Name

CDKN1A

UniProt

P38936

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic phosphopeptide derived from human p21 around the phosphorylation site of Threonine 145.

Clonality

Polyclonal

Tissue Specificity

Expressed in all adult tissues, with 5-fold lower levels observed in the brain.

Applications

IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

18119 MW

Applications Notes

IHC: 1:50-1:200

Gene Name Synonym

Cyclin-dependent kinase inhibitor 1

Subcellular Location

Cytoplasm. Nucleus.

Protein Name

Cyclin-dependent kinase inhibitor 1

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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