Anti-MyD88 Antibody
Boster Bio Anti-MyD88 Antibody catalog # A00025. Tested in WB, ICC/IF, IHC, Flow Cytometry applications. This antibody reacts with Human.
Product Specifications
Synonyms
Myeloid differentiation primary response protein MyD88; MYD88
Gene Name
MYD88
UniProt
Q99836
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant protein
Clonality
Polyclonal
Tissue Specificity
Ubiquitous.
Applications
WB, ICC, IF, IHC, Flow Cytometry
Purification
ProA affinity purified
Concentration
1 mg/mL
Form
Liquid
Function
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575) . Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:24316379, PubMed:19506249) . Increases IL-8 transcription (PubMed:9013863) . Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
33233 MW
Gene Name Synonym
Myeloid differentiation primary response protein MyD88
Subcellular Location
Cytoplasm
Protein Name
Myeloid differentiation primary response protein MyD88
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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