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Anti-TGFB1 Antibody

Boster Bio Anti-TGFB1 Antibody (Catalog # A00019-1) . Tested in WB application (s) . This antibody reacts with Human, Rat.

Product Specifications

Background

Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.

Synonyms

Transforming growth factor beta-1, TGF-beta-1, Latency-associated peptide, LAP, TGFB1, TGFB

Gene Name

TGFB1

UniProt

P01137

Host

Rabbit

Reactivity

Human, Rat

Immunogen

This TGFB1 antibody is generated from a rabbit immunized with a recombinant protein of human TGFB1.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in bone (PubMed:11746498, PubMed:17827158) . Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) (PubMed:11746498, PubMed:17827158) . Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage (PubMed:17827158)

Applications

WB

Field of Research

Cancer, Cardiovascular, Developmental Biology, Metabolism, Signal Transduction, Stem Cells, Cytokines

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/mL.

Function

Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

44341 Da

Applications Notes

WB: 1:2000

Subcellular Location

[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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