Diaziquone
Diaziquone (NSC 182986), an aziridinylbenzoquinone, is a DNA alkylating agent. Diaziquone shows a broad antitumor activity against numerous transplantable murine tumors including curative activity against several intracerebrally implanted tumors. Diaziquone crosses the blood brain barrier[1][2].
Product Specifications
CAS Number
[57998-68-2]
Product Name Alternative
NSC 182986
UNSPSC
12352005
Target
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/diaziquone.html
Purity
98.46
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C(N1CC1)=C(C2=O)NC(OCC)=O)C(NC(OCC)=O)=C2N3CC3
Molecular Formula
C16H20N4O6
Molecular Weight
364.35
References & Citations
[1]S C Schold Jr, et al. Treatment of human glioma and medulloblastoma tumor lines in athymic mice with diaziquone and diaziquone-based drug combinations. Cancer Res. 1984 Jun;44 (6) :2352-7.|[2]Bender JF, et al. Diaziquone (AZQ) . Invest New Drugs. 1983;1 (1) :71-84.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
043388-ML550 100 µL
TSPYL1, CT (TSPYL1, TSPYL, Testis-specific Y-encoded-like protein 1) (MaxLight 550) discontinued
Ask
View Details