Anti-Twinkle/TWNK Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The protein localizes to the mitochondrial matrix and mitochondrial nucleoids. Mutations in this gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms
TWNK; C10orf2; PEO1; Twinkle protein, mitochondrial; EC 3.6.4.12; Progressive external ophthalmoplegia 1 protein; T7 gp4-like protein with intramitochondrial nucleoid localization; T7-like mitochondrial DNA helicase; Twinkle mtDNA helicase
Gene Name
TWNK
Gene ID
56652
UniProt
Q96RR1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human Twinkle/TWNK recombinant protein (Position: R39-K635) . Human Twinkle/TWNK shares 87.8% amino acid (aa) sequence identity with mouse Twinkle/TWNK.
Clonality
Polyclonal
Applications
Flow Cytometry
Purification
Immunogen affinity purified.
Form
Liquid
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A32117-Fluoro647
Calculated Molecular Weight
77 kDa
Applications Notes
6
Gene Name Synonym
Twinkle mtDNA helicase
Protein Name
Twinkle mtDNA helicase
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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