Anti-PARL Antibody Picoband® APC Conjugated

This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease.

PARL; PSARL; PRO2207; Presenilins-associated rhomboid-like protein, mitochondrial; EC 3.4.21.105; Mitochondrial intramembrane cleaving protease PARL [Cleaved into: P-beta; Pbeta]

A synthetic peptide corresponding to a sequence in the middle region of human PARL. Human PARL shares 98.8% amino acid (aa) sequence identity with both mouse and rat PARL.