Anti-LAP2/TMPO Antibody Picoband® FITC Conjugated

Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each other when acting to chaperone other proteins and regulate transcription.

TMPO; LAP2; Lamina-associated polypeptide 2, isoform alpha; Thymopoietin isoform alpha; TP alpha; Thymopoietin-related peptide isoform alpha; TPRP isoform alpha [Cleaved into: Thymopoietin; TP; Splenin; Thymopentin; TP5]

E.coli-derived human LAP2/TMPO recombinant protein (Position: N24-P672) . Human LAP2/TMPO shares 78.8% amino acid (aa) sequence identity with mouse LAP2/TMPO.