Anti-REST Antibody Picoband® HRP Conjugated

This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described.

E.coli-derived human REST recombinant protein (Position: E110-E1097) . Human REST shares 62.9% and 59.6% amino acid (aa) sequence identity with mouse and rat REST, respectively.