Anti-RB1 Antibody Picoband® HRP Conjugated

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

E.coli-derived human RB1 recombinant protein (Position: E40-D921) . Human RB1 shares 91.6% and 90.7% amino acid (aa) sequence identity with mouse and rat RB1, respectively.