Anti-POLD1 Antibody Picoband® PE Conjugated

This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6.

E.coli-derived human POLD1 recombinant protein (Position: D25-D1068) . Human POLD1 shares 89.5% and 90.2% amino acid (aa) sequence identity with mouse and rat POLD1, respectively.

1. Bellido, F., Pineda, M., Aiza, G., Valdes-Mas, R., Navarro, M., Puente, D. A., Pons, T., Gonzalez, S., Iglesias, S., Darder, E., Pinol, V., Soto, J. L., Valencia, A., Blanco, I., Urioste, M., Brunet, J., Lazaro, C., Capella, G., Puente, X. S., Valle, L. POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillance. Genet. Med. 18: 325-332, 2016. 2. Chang, L.-S., Zhao, L., Zhu, L., Chen, M.-L., Lee, M. Y. W. T. Structure of the gene for the catalytic subunit of human DNA polymerase delta (POLD1) . Genomics 28: 411-419, 1995. 3. Chung, D. W., Zhang, J., Tan, C.-K., Davie, E. W., So, A. G., Downey, K. M. Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene. Proc. Nat. Acad. Sci. 88: 11197-11201, 1991.