Anti-POLD1 Antibody Picoband® Biotin Conjugated
Product Specifications
Background
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6.
Synonyms
POLD1; POLD; DNA polymerase delta catalytic subunit; EC 2.7.7.7; 3'-5' exodeoxyribonuclease; EC 3.1.11.-; DNA polymerase subunit delta p125
Gene Name
POLD1
Gene ID
5424
UniProt
P28340
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human POLD1 recombinant protein (Position: D25-D1068) . Human POLD1 shares 89.5% and 90.2% amino acid (aa) sequence identity with mouse and rat POLD1, respectively.
Clonality
Polyclonal
Applications
WB, IHC, ELISA
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Bellido, F., Pineda, M., Aiza, G., Valdes-Mas, R., Navarro, M., Puente, D. A., Pons, T., Gonzalez, S., Iglesias, S., Darder, E., Pinol, V., Soto, J. L., Valencia, A., Blanco, I., Urioste, M., Brunet, J., Lazaro, C., Capella, G., Puente, X. S., Valle, L. POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillance. Genet. Med. 18: 325-332, 2016. 2. Chang, L.-S., Zhao, L., Zhu, L., Chen, M.-L., Lee, M. Y. W. T. Structure of the gene for the catalytic subunit of human DNA polymerase delta (POLD1) . Genomics 28: 411-419, 1995. 3. Chung, D. W., Zhang, J., Tan, C.-K., Davie, E. W., So, A. G., Downey, K. M. Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene. Proc. Nat. Acad. Sci. 88: 11197-11201, 1991.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.
Calculated Molecular Weight
124 kDa
Gene Name Synonym
DNA polymerase delta 1, catalytic subunit
Protein Name
DNA polymerase delta catalytic subunit
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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