Anti-POLM Antibody Picoband® APC Conjugated

Predicted to enable DNA-directed DNA polymerase activity. Predicted to be involved in double-strand break repair via nonhomologous end joining. Predicted to act upstream of or within B cell differentiation and somatic hypermutation of immunoglobulin genes. Predicted to be located in nucleoplasm. Predicted to be active in nucleus.

1. Aoufouchi, S., Flatter, E., Dahan, A., Faili, A., Bertocci, B., Storck, S., Delbos, F., Cocea, L., Gupta, N., Weill, J.-C., Reynaud, C.-A. Two novel human and mouse DNA polymerases of the polX family. Nucleic Acids Res. 28: 3684-3693, 2000. 2. Bertocci, B., De Smet, A., Berek, C., Weill, J.-C., Reynaud, C.-A. Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu. Immunity 19: 203-211, 2003. 3. Bertocci, B., De Smet, A., Flatter, E., Dahan, A., Bories, J.-C., Landreau, C., Weill, J.-C., Reynaud, C.-A. Cutting edge: DNA polymerase mu and lambda are dispensable for Ig gene hypermutation. J. Immun. 168: 3702-3706, 2002.