Anti-PLCD1 Antibody Picoband® APC Conjugated

This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3) . The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; EC 3.1.4.11; Phosphoinositide phospholipase C-delta-1; Phospholipase C-III; PLC-III; Phospholipase C-delta-1; PLC-delta-1

E.coli-derived human PLCD1 recombinant protein (Position: Q14-R549) . Human PLCD1 shares 92.2% and 92.5% amino acid (aa) sequence identity with mouse and rat PLCD1, respectively.

1. Berridge, M. J. Inositol trisphosphate and calcium signalling. Nature 361: 315-325, 1993. 2. Cheng, H. F., Jiang, M. J., Chen, C. L., Liu, S. M., Wong, L. P., Lomasney, J. W., King, K. Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis. J. Biol. Chem. 270: 5495-5505, 1995. 3. Hu, X.-T., Zhang, F.-B., Fan, Y.-C., Shu, X.-S., Wong, A. H. Y., Zhou, W., Shi, Q.-L., Tang, H.-M., Fu, L., Guan, X.-Y., Rha, S. Y., Tao, Q., He, C. Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer. Oncogene 28: 2466-2475, 2009.