Anti-PIK3C2A Antibody Picoband® Biotin Conjugated

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.

PIK3C2A; Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; PI3K-C2-alpha; PtdIns-3-kinase C2 subunit alpha; EC 2.7.1.154; Phosphoinositide 3-kinase-C2-alpha

E.coli-derived human PIK3C2A recombinant protein (Position: R22-E1523) . Human PIK3C2A shares 89.7% amino acid (aa) sequence identity with mouse PIK3C2A.

1. Caldwell, G. M., Eddy, R. L., Day, C. D., Haley, L. H., Cooper, P. R., Sait, S. S. J., Hejtmancik, F., Smith, R. J. H., Morton, C. C., Higgins, M. J., Shows, T. B. Mapping of genes and transcribed sequences in a gene rich 400-kb region on human chromosome 11p15.1-p14. Cytogenet. Cell Genet. 92: 103-107, 2001. 2. Domin, J., Pages, F., Volinia, S., Rittenhouse, S. E., Zvelebil, M. J., Stein, R. C., Waterfield, M. D. Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. Biochem. J. 326: 139-147, 1997. 3. Molz, L., Chen, Y.-W., Hirano, M., Williams, L. T. Cpk is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain. J. Biol. Chem. 271: 13892-13899, 1996.