Anti-PIF1 Antibody Picoband® APC Conjugated

This gene encodes a DNA-dependent adenosine triphosphate (ATP) -metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telomere elongation by inhibiting the actions of telomerase. Alternative splicing and the use of alternative start codons results in multiple isoforms that are differentially localized to either the mitochondria or the nucleus.

E.coli-derived human PIF1 recombinant protein (Position: Q31-R618) . Human PIF1 shares 87.6% and 87.8% amino acid (aa) sequence identity with mouse and rat PIF1, respectively.

1. Mateyak, M. K., Zakian, V. A. Human PIF helicase is cell cycle regulated and associates with telomerase. Cell Cycle 5: 2796-2804, 2006. 2. Paeschke, K., Bochman, M. L., Garcia, P. D., Cejka, P., Friedman, K. L., Kowalczykowski, S. C., Zakian, V. A. Pif1 family helicases suppress genome instability at G-quadruplex motifs. Nature 497: 458-462, 2013. 3. Zhang, D.-H., Zhou, B., Huang, Y., Xu, L.-X., Zhou, J.-Q. The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity. Nucleic Acids Res. 34: 1393-1404, 2006.