Anti-PDZK1 Antibody Picoband® Biotin Conjugated

Predicted to enable PDZ domain binding activity; protein-membrane adaptor activity; and scavenger receptor binding activity. Involved in positive regulation of protein targeting to membrane; protein localization to plasma membrane; and regulation of monoatomic anion transport. Acts upstream of or within in utero embryonic development. Located in brush border membrane. Is expressed in several structures, including genitourinary system; liver; lung; thymus; and white fat. Orthologous to several human genes including PDZK1 (PDZ domain containing 1) .

Pdzk1; Cap70; Nherf3; Na (+/H (+ exchange regulatory cofactor NHE-RF3; NHERF-3; CFTR-associated protein of 70 kDa; Na (+/H (+ exchanger regulatory factor 3; Na/Pi cotransporter C-terminal-associated protein 1; NaPi-Cap1; PDZ domain-containing protein 1; Sodium-hydrogen exchanger regulatory factor 3

E.coli-derived mouse PDZK1 recombinant protein (Position: R8-R502) . Mouse PDZK1 shares 78% and 91.4% amino acid (aa) sequence identity with human and rat PDZK1, respectively.

1. Custer, M., Spindler, B., Verrey, F., Murer, H., Biber, J. Identification of a new gene product (diphor-1) regulated by dietary phosphate. Am. J. Physiol. 273: F801-F806, 1997. 2. Fanning, A. S., Anderson, J. M. PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane. J. Clin. Invest. 103: 767-772, 1999. 3. Ikemoto, M., Arai, H., Feng, D., Tanaka, K., Aoki, J., Dohmae, N., Takio, K., Adachi, H., Tsujimoto, M., Inoue, K. Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I. Proc. Nat. Acad. Sci. 97: 6538-6543, 2000.