Anti-GGCT Antibody Picoband® APC Conjugated

The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

1. Bissbort, S., Bender, K., Grzeschik, K. H. Assignment of the human gene for gamma-glutamyl-cyclo-transferase (GCTG) to chromosome 7p. (Abstract) Cytogenet. Cell Genet. 37: 442 only, 1984. 2. Masuda, Y., Maeda, S., Watanabe, A., Sano, Y., Aiuchi, T., Nakajo, S., Itabe, H., Nakaya, K. A novel 21-kDa cytochrome c-releasing factor is generated upon treatment of human leukemia U937 cells with geranylgeraniol. Biochem. Biophys. Res. Commun. 346: 454-460, 2006. 3. Oakley, A. J., Yamada, T., Liu, D., Coggan, M., Clark, A. G., Board, P. G. The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase: an essential enzyme in the gamma-glutamyl cycle. J. Biol. Chem. 283: 22031-22042, 2008. Note: Erratum: J. Biol. Chem. 283: 32152 only, 2008.