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Anti-EVC2 Antibody Picoband® APC Conjugated

Product Specifications

Background

Involved in smoothened signaling pathway. Located in ciliary membrane and nucleus. Part of plasma membrane protein complex. Is expressed in several structures, including bone; heart; jaw; nose; and paranasal sinus. Used to study Ellis-Van Creveld syndrome. Human ortholog (s) of this gene implicated in Ellis-Van Creveld syndrome and Weyers acrofacial dysostosis. Orthologous to human EVC2 (EvC ciliary complex subunit 2) .

Synonyms

Evc2; Lbn; Limbin

Gene Name

EVC2

Gene ID

68525

UniProt

Q8K1G2

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived mouse EVC2 recombinant protein (Position: Q379-D901) . Mouse EVC2 shares 76.6% amino acid (aa) sequence identity with human EVC2.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Adachi, N., Lieber, M. R. Bidirectional gene organization: a common architectural feature of the human genome. Cell 109: 807-809, 2002. 2. Caparros-Martin, J. A., Valencia, M., Reytor, E., Pacheco, M., Fernandez, M., Perez-Aytes, A., Gean, E., Lapunzina, P., Peters, H., Goodship, J. A., Ruiz-Perez, V. L. The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia. Hum. Molec. Genet. 22: 124-139, 2013. 3. D'Asdia, M. C., Torrente, I., Consoli, F., Ferese, R., Magliozzi, M., Bernardini, L., Guida, V., Digilio, M. C., Marino, B., Dallapicolla, B., De Luca, A. Novel and recurrent EVC and EVC2 mutations in Ellis-van Creveld syndrome and Weyers acrofacial dysostosis. Europ. J. Med. Genet. 56: 80-87, 2013.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

148 kDa

Applications Notes

6

Gene Name Synonym

EvC ciliary complex subunit 2

Protein Name

Limbin

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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