Anti-SHMT2 Antibody Picoband® HRP Conjugated

This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants.

1. Bogenhagen, D. F., Rousseau, D., Burke, S. The layered structure of human mitochondrial DNA nucleoids. J. Biol. Chem. 283: 3665-3675, 2008. 2. Cao, J., Sun, L., Aramsangtienchai, P., Spiegelman, N. A., Zhang, X., Huang, W., Seto, E., Lin, H. HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2. Proc. Nat. Acad. Sci. 116: 5487-5492, 2019. 3. Garcia-Cazorla, A., Verdura, E., Julia-Palacios, N., Anderson, E. N., Goicoechea, L., Planas-Serra, L., Tsogtbaatar, E., Dsouza, N. R., Schluter, A., Urreizti, R. Tarnowski, J. M., Gavrilova, R. H., and 15 others. Impairment of the mitochondrial one-carbon metabolism enzyme SHMT2 causes a novel brain and heart developmental syndrome. Acta Neuropath. 140: 971-975, 2020.