Anti-ADAM12 Antibody Picoband® Fluoro488 Conjugated

This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form.

1. Galliano, M.-F., Huet, C., Frygelius, J., Polgren, A., Wewer, U. M., Engvall, E. Binding of ADAM12, a marker of skeletal muscle regeneration, to the muscle-specific actin-binding protein, alpha-actinin-2, is required for myoblast fusion. J. Biol. Chem. 275: 13933-13939, 2000. 2. Gilpin, B. J., Loechel, F., Mattei, M.-G., Engvall, E., Albrechtsen, R., Wewer, U. M. A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo. J. Biol. Chem. 273: 157-166, 1998. 3. Kurisaki, T., Masuda, A., Sudo, K., Sakagami, J., Higashiyama, S., Matsuda, Y., Nagabukuro, A., Tsuji, A., Nabeshima, Y., Asano, M., Iwakura, Y., Sehara-Fujisawa, A. Phenotypic analysis of meltrin alpha (ADAM12) -deficient mice: involvement of meltrin alpha in adipogenesis and myogenesis. Molec. Cell. Biol. 23: 55-61, 2003.