Anti-NTN4 Antibody Picoband® APC Conjugated

This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants.

1. Koch, M., Murrell, J. R., Hunter, D. D., Olson, P. F., Jin, W., Keene, D. R., Brunken, W. J., Burgeson, R. E. A novel member of the netrin family, beta-netrin, shares homology with the beta chain of laminin: identification, expression, and functional characterization. J. Cell Biol. 151: 221-234, 2000. 2. Larrieu-Lahargue, F., Welm, A. L., Thomas, K. R., Li, D. Y. Netrin-4 induces lymphangiogenesis in vivo. Blood 115: 5418-5426, 2010. 3. Zhang, C., Meng, F., Wang, C., Guo, H., Fan, M., Liu, S., Zhou, R., He, F. Identification of a novel alternative splicing form of human netrin-4 and analyzing the expression patterns in adult rat brain. Molec. Brain Res. 130: 68-80, 2004.