Anti-SUPT16H Antibody Picoband® HRP Conjugated

Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit.

SUPT16H; FACT140; FACTP140; FACT complex subunit SPT16; Chromatin-specific transcription elongation factor 140 kDa subunit; FACT 140 kDa subunit; FACTp140; Facilitates chromatin transcription complex subunit SPT16; hSPT16

E.coli-derived human SUPT16H recombinant protein (Position: M1-E926) . Human SUPT16H shares 98.6% amino acid (aa) sequence identity with mouse SUPT16H.

1. Belotserkovskaya, R., Oh, S., Bondarenko, V. A., Orphanides, G., Studitsky, V. M., Reinberg, D. FACT facilitates transcription-dependent nucleosome alteration. Science 301: 1090-1093, 2003. 2. Bina, R., Matalon, D., Fregeau, B., Tarsitano, J. J., Aukrust, I., Houge, G., Bend, R., Warren, H., Stevenson, R. E., Stuurman, K. E., Barkovich, A. J., Sherr, E. H. De novo variants in SUPT16H cause neurodevelopmental disorders associated with corpus callosum abnormalities. J. Med. Genet. 57: 461-465, 2020. 3. Keller, D. M., Zeng, X., Wang, Y., Zhang, Q. H., Kapoor, M., Shu, H., Goodman, R., Lozano, G., Zhao, Y., Lu, H. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. Molec. Cell 7: 283-292, 2001.