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Anti-NLRP6 Antibody Picoband® Biotin Conjugated

Product Specifications

Background

The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms

NLRP6; NALP6; PYPAF5; NACHT, LRR and PYD domains-containing protein 6; Angiotensin II/vasopressin receptor; PYRIN-containing APAF1-like protein 5

Gene Name

NLRP6

Gene ID

171389

UniProt

P59044

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human NLRP6 recombinant protein (Position: R14-E887) . Human NLRP6 shares 71.7% and 72.9% amino acid (aa) sequence identity with mouse and rat NLRP6, respectively.

Clonality

Polyclonal

Applications

WB, IHC, ELISA

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Anand, P. K., Malireddi, R. K. S., Lukens, J. R., Vogel, P., Bertin, J., Lamkanfi, M., Kanneganti, T.-D. NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Nature 488: 389-393, 2012. 2. Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R., Bertin, J., Eisenbarth, S. C., Gordon, J. I., Flavell, R. A. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145: 745-757, 2011. 3. Grenier, J. M., Wang, L., Manji, G. A., Huang, W.-J., Al-Garawi, A., Kelly, R., Carlson, A., Merriam, S., Lora, J. M., Briskin, M., DiStefano, P. S., Bertin, J. Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappa-B and caspase-1. FEBS Lett. 530: 73-78, 2002.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

Calculated Molecular Weight

99 kDa

Gene Name Synonym

NLR family pyrin domain containing 6

Protein Name

NACHT, LRR and PYD domains-containing protein 6

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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