Anti-NLRP6 Antibody Picoband® Biotin Conjugated
Product Specifications
Background
The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms
NLRP6; NALP6; PYPAF5; NACHT, LRR and PYD domains-containing protein 6; Angiotensin II/vasopressin receptor; PYRIN-containing APAF1-like protein 5
Gene Name
NLRP6
Gene ID
171389
UniProt
P59044
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human NLRP6 recombinant protein (Position: R14-E887) . Human NLRP6 shares 71.7% and 72.9% amino acid (aa) sequence identity with mouse and rat NLRP6, respectively.
Clonality
Polyclonal
Applications
WB, IHC, ELISA
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Anand, P. K., Malireddi, R. K. S., Lukens, J. R., Vogel, P., Bertin, J., Lamkanfi, M., Kanneganti, T.-D. NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Nature 488: 389-393, 2012. 2. Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R., Bertin, J., Eisenbarth, S. C., Gordon, J. I., Flavell, R. A. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145: 745-757, 2011. 3. Grenier, J. M., Wang, L., Manji, G. A., Huang, W.-J., Al-Garawi, A., Kelly, R., Carlson, A., Merriam, S., Lora, J. M., Briskin, M., DiStefano, P. S., Bertin, J. Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappa-B and caspase-1. FEBS Lett. 530: 73-78, 2002.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.
Calculated Molecular Weight
99 kDa
Gene Name Synonym
NLR family pyrin domain containing 6
Protein Name
NACHT, LRR and PYD domains-containing protein 6
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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