Anti-NLRP6 Antibody Picoband®

The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene.

E.coli-derived human NLRP6 recombinant protein (Position: R14-E887) . Human NLRP6 shares 71.7% and 72.9% amino acid (aa) sequence identity with mouse and rat NLRP6, respectively.

1. Anand, P. K., Malireddi, R. K. S., Lukens, J. R., Vogel, P., Bertin, J., Lamkanfi, M., Kanneganti, T.-D. NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Nature 488: 389-393, 2012. 2. Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R., Bertin, J., Eisenbarth, S. C., Gordon, J. I., Flavell, R. A. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145: 745-757, 2011. 3. Grenier, J. M., Wang, L., Manji, G. A., Huang, W.-J., Al-Garawi, A., Kelly, R., Carlson, A., Merriam, S., Lora, J. M., Briskin, M., DiStefano, P. S., Bertin, J. Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappa-B and caspase-1. FEBS Lett. 530: 73-78, 2002.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.