Anti-NCDN Antibody Picoband®

This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described.

E.coli-derived human NCDN recombinant protein (Position: F114-K426) . Human NCDN shares 98.1% and 97.4% amino acid (aa) sequence identity with mouse and rat NCDN, respectively.

1. Fatima, A., Hoeber, J., Schuster, J., Koshimizu, E., Maya-Gonzalez, C., Keren, B., Mignot, C., Akram, T., Ali, Z., Miyatake, S., Tanigawa, J., Koike, T., and 14 others. Monoallelic and bi-allelic variants in NCDN cause neurodevelopmental delay, intellectual disability, and epilepsy. Am. J. Hum. Genet. 108: 739-748, 2021. Note: Erratum: Am. J. Hum. Genet. 109: 542-546, 2022. 2. Mochizuki, R., Dateki, M., Yanai, K., Ishizuka, Y., Amizuka, N., Kawashima, H., Koga, Y., Ozawa, H., Fukamizu, A. Targeted disruption of the neurochondrin/norbin gene results in embryonic lethality. Biochem. Biophys. Res. Commun. 310: 1219-1226, 2003. 3. Mochizuki, R., Ishizuka, Y., Yanai, K., Murakami, K., Koga, Y., Fukamizu, A. Molecular cloning and expression of human neurochondrin-1 and -2. Biochim. Biophys. Acta 1446: 397-402, 1999. Note: Erratum: Biochim. Biophys. Acta 1490: 367-368, 2000.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.