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Anti-Histone H4 Antibody Picoband® Biotin Conjugated

Product Specifications

Background

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4) . The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.

Synonyms

H4C1; H4/A; H4FA; HIST1H4A; ; H4C2; H4/I; H4FI; HIST1H4B; ; H4C3; H4/G; H4FG; HIST1H4C; ; H4C4; H4/B; H4FB; HIST1H4D; ; H4C5; H4/J; H4FJ; HIST1H4E; ; H4C6; H4/C; H4FC; HIST1H4F; ; H4C8; H4/H; H4FH; HIST1H4H; ; H4C9; H4/M; H4FM; HIST1H4I; ; H4C11; H4/E; H4FE; HIST1H4J; ; H4C12; H4/D; H4FD; HIST1H4K; ; H4C13; H4/K; H4FK; HIST1H4L; ; H4C14; H4/N; H4F2; H4FN; HIST2H4; HIST2H4A; ; H4C15; H4/O; H4FO; HIST2H4B; ; H4-16; HIST4H4; Histone H4

Gene Name

H4C1/2/3/4/5/6/8/9/11/12/13/14/15/16

Gene ID

8370

UniProt

P62805

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human Histone H4 recombinant protein (Position: A16-R96) .

Clonality

Polyclonal

Applications

WB, IHC, ELISA

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Agalioti, T., Chen, G., Thanos, D. Deciphering the transcriptional histone acetylation code for a human gene. Cell 111: 381-392, 2002. 2. Albig, W., Kioschis, P., Poustka, A., Meergans, K., Doenecke, D. Human histone gene organization: nonregular arrangement within a large cluster. Genomics 40: 314-322, 1997. 3. Allen, B., Ostrer, H., Stein, J., Stein, G. Histone gene clusters map to chromosomes 1 and 6. (Abstract) Cytogenet. Cell Genet. 51: 950 only, 1989.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

Calculated Molecular Weight

11 kDa

Gene Name Synonym

H4 clustered histone 14

Protein Name

Histone H4

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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