Anti-PDC Antibody Picoband® PE Conjugated

This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified.

E.coli-derived human PDC recombinant protein (Position: M1-E246) . Human PDC shares 88.2% and 87.8% amino acid (aa) sequence identity with mouse and rat PDC, respectively.

1. Abe, T., Kikuchi, T., Shinohara, T. The sequence of the human phosducin gene (PDC) and its 5-prime-flanking region. Genomics 19: 369-372, 1994. 2. Craft, C. M., Lolley, R. N., Seldin, M. F., Lee, R. H. Rat pineal gland phosducin: cDNA isolation, nucleotide sequence, and chromosomal assignment in the mouse. Genomics 10: 400-409, 1991. 3. Ding, C., Li, X., Griffin, C. A., Jabs, E. W., Hawkins, A. L., Levine, M. A. The gene for human phosducin (PDC), a soluble protein that binds G-protein beta gamma dimers, maps to 1q25-q31.1. Genomics 18: 457-459, 1993.