Perforin-IN-2

Perforin-IN-2 (Compound 1) is the inhibitor for perforin that inhibits perforin-mediated cell lysis, thereby reducing graft rejection during allogeneic bone marrow/stem cell transplantation[1].

Product Specifications

CAS Number

[1567836-70-7]

UNSPSC

12352005

Target

Complement System

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/perforin-in-2.html

Purity

99.43

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=C(CN1C)C=C(C3=CC=C(C4=CN=CC(NS(=O)(C5=C([N+]([O-])=O)C=CC=C5)=O)=C4)S3)C=C2

Molecular Formula

C24H18N4O5S2

Molecular Weight

506.55

References & Citations

[1]Gartlan KH, et al. Preclinical Activity and Pharmacokinetic/Pharmacodynamic Relationship for a Series of Novel Benzenesulfonamide Perforin Inhibitors. ACS Pharmacol Transl Sci. 2022 May 31;5 (6) :429-439.