Anti-SCAP Antibody Picoband®

This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. Alternative splicing results in multiple transcript variants.

E.coli-derived human SCAP recombinant protein (Position: F1224-D1279) . Human SCAP shares 100% amino acid (aa) sequence identity with both mouse and rat SCAP.

1. Brown, A. J., Sun, L., Feramisco, J. D., Brown, M. S., Goldstein, J. L. Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism. Molec. Cell 10: 237-245, 2002. 2. Cao, H., Miskie, B. A., Hegele, R. A. Functional promoter polymorphism in SREBP cleavage-activating protein (SCAP) . J. Hum. Genet. 47: 492-496, 2002. 3. DeBose-Boyd, R. A., Brown, M. S., Li, W.-P., Nohturfft, A., Goldstein, J. L., Espenshade, P. J. Transport-dependent proteolysis of SREBP: relocation of Site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. Cell 99: 703-712, 1999.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.